AmyP53 Prevents the Formation of Neurotoxic β-Amyloid Oligomers through an Unprecedent Mechanism of Interaction with Gangliosides: Insights for Alzheimer’s Disease Therapy
A broad range of data identify Ca<sup>2+</sup>-permeable amyloid pores as the most neurotoxic species of Alzheimer’s β-amyloid peptide (Aβ<sub>1–42</sub>). Following the failures of clinical trials targeting amyloid plaques by immunotherapy, a consensus is gradually emerging...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/2/1760 |