AmyP53 Prevents the Formation of Neurotoxic β-Amyloid Oligomers through an Unprecedent Mechanism of Interaction with Gangliosides: Insights for Alzheimer’s Disease Therapy

AmyP53 Prevents the Formation of Neurotoxic β-Amyloid Oligomers through an Unprecedent Mechanism of Interaction with Gangliosides: Insights for Alzheimer’s Disease Therapy

A broad range of data identify Ca<sup>2+</sup>-permeable amyloid pores as the most neurotoxic species of Alzheimer’s β-amyloid peptide (Aβ<sub>1–42</sub>). Following the failures of clinical trials targeting amyloid plaques by immunotherapy, a consensus is gradually emerging...

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Bibliographic Details
Main Authors:	Fodil Azzaz, Henri Chahinian, Nouara Yahi, Jacques Fantini, Coralie Di Scala
Format:	Article
Language:	English
Published:	MDPI AG 2023-01-01
Series:	International Journal of Molecular Sciences
Subjects:	Alzheimer Parkinson lipid raft ganglioside oligomer amyloid pore
Online Access:	https://www.mdpi.com/1422-0067/24/2/1760

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