Aloe-emodin exhibits growth-suppressive effects on androgen-independent human prostate cancer DU145 cells via inhibiting the Wnt/β-catenin signaling pathway: an in vitro and in silico study

Aloe-emodin exhibits growth-suppressive effects on androgen-independent human prostate cancer DU145 cells via inhibiting the Wnt/β-catenin signaling pathway: an in vitro and in silico study

At the molecular level, several developmental signaling pathways, such as Wnt/β-catenin, have been associated with the initiation and subsequent progression of prostate carcinomas. The present report elucidated the anti-cancerous attributes of an anthraquinone, aloe-emodin (AE), against androgen-ind...

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Bibliographic Details
Main Authors: Talib Hussain, Ahmed Alafnan, Ibrahim Abdullah Almazni, Nawal Helmi, Afrasim Moin, Hanadi M. Baeissa, Amir Mahgoub Awadelkareem, AbdElmoneim O. Elkhalifa, Tahani Bakhsh, Abdulrahman Alzahrani, Rashed Mohammed Alghamdi, Mohammad Khalid, Rohit Kumar Tiwari, Syed Mohd Danish Rizvi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Pharmacology
Subjects:
aloe-emodin
ROS
DU145 cells
caspases
mitochondrial viability
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1325184/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1325184/full

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