SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability

SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability

Abstract Innervation of the hypothalamic median eminence by Gonadotropin-Releasing Hormone (GnRH) neurons is vital to ensure puberty onset and successful reproduction. However, the molecular and cellular mechanisms underlying median eminence development and pubertal timing are incompletely understoo...

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Detalhes bibliográficos
Principais autores: Antonella Lettieri, Roberto Oleari, Marleen Hester van den Munkhof, Eljo Yvette van Battum, Marieke Geerte Verhagen, Carlotta Tacconi, Marco Spreafico, Alyssa Julia Jennifer Paganoni, Roberta Azzarelli, Valentina Andre’, Federica Amoruso, Luca Palazzolo, Ivano Eberini, Leo Dunkel, Sasha Rose Howard, Alessandro Fantin, Ronald Jeroen Pasterkamp, Anna Cariboni
Formato: Artigo
Idioma:English
Publicado em: Nature Portfolio 2023-12-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-023-43820-z

Internet

https://doi.org/10.1038/s41467-023-43820-z

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