Mechanotransduction in high aspect ratio nanostructured meta-biomaterials: The role of cell adhesion, contractility, and transcriptional factors

Mechanotransduction in high aspect ratio nanostructured meta-biomaterials: The role of cell adhesion, contractility, and transcriptional factors

Black Ti (bTi) surfaces comprising high aspect ratio nanopillars exhibit a rare combination of bactericidal and osteogenic properties, framing them as cell-instructive meta-biomaterials. Despite the existing data indicating that bTi surfaces induce osteogenic differentiation in cells, the mechanisms...

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Bibliographic Details
Main Authors: Khashayar Modaresifar, Mahya Ganjian, Pedro J. Díaz-Payno, Maria Klimopoulou, Marijke Koedam, Bram C.J. van der Eerden, Lidy E. Fratila-Apachitei, Amir A. Zadpoor
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Materials Today Bio
Subjects:
High aspect ratio nanopillars
Osteogenic response
Mechanotransduction
Focal adhesion kinase
Rho-associated protein kinase
Yes-associated protein
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006422002460

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http://www.sciencedirect.com/science/article/pii/S2590006422002460

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