One-step visualization of natural cell activities in non-labeled living spheroids

Abstract 3D cultured cell aggregates, including spheroids, reflect the gene expression patterns of living tissues/organs. Mass preparation of spheroids enables high-throughput drug screening (HTS). However, conventional optical imaging of spheroids makes it difficult to obtain sufficient resolution...

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Bibliographic Details
Main Authors: Shotaro Tanaka, Kotaro Takizawa, Fumio Nakamura
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-05347-z