Consolidated BRCA1/2 Variant Interpretation by MH BRCA Correlates with Predicted PARP Inhibitor Efficacy Association by MH Guide

Consolidated BRCA1/2 Variant Interpretation by MH BRCA Correlates with Predicted PARP Inhibitor Efficacy Association by MH Guide

<i>BRCA1/2</i> variants are prognostic biomarkers for hereditary breast and/or ovarian cancer (HBOC) syndrome and predictive biomarkers for PARP inhibition. In this study, we benchmarked the classification of <i>BRCA1/2</i> variants from patients with HBOC-related cancer usin...

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Bibliographic Details
Main Authors: Yosuke Hirotsu, Udo Schmidt-Edelkraut, Hiroshi Nakagomi, Ikuko Sakamoto, Markus Hartenfeller, Ram Narang, Theodoros G. Soldatos, Sajo Kaduthanam, Xiaoyue Wang, Stephan Hettich, Stephan Brock, David B. Jackson, Masao Omata
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
<i>BRCA1</i>
<i>BRCA2</i>
PARP inhibition
HBOC
cancer
Online Access:https://www.mdpi.com/1422-0067/21/11/3895

Internet

https://www.mdpi.com/1422-0067/21/11/3895

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