Patterns of Mitochondrial TSPO Binding in Cerebral Small Vessel Disease: An in vivo PET Study With Neuropathological Comparison

Patterns of Mitochondrial TSPO Binding in Cerebral Small Vessel Disease: An in vivo PET Study With Neuropathological Comparison

Small vessel disease (SVD) is associated with cognitive impairment in older age and be implicated in vascular dementia. Post-mortem studies show proliferation of activated microglia in the affected white matter. However, the role of inflammation in SVD pathogenesis is incompletely understood and bet...

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Bibliographic Details
Main Authors: Paul Wright, Mattia Veronese, Ndabezinhle Mazibuko, Federico E. Turkheimer, Eugenii A. Rabiner, Clive G. Ballard, Steven C. R. Williams, Avinash Kumar Hari Narayanan, Bahiya Osrah, Ricky Williams, Tiago R. Marques, Oliver D. Howes, Federico Roncaroli, Michael J. O'Sullivan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Neurology
Subjects:
microglia
PET—positron emission tomography
TSPO (18 kda translocator protein)
small vessel disease (SVD)
immunohistochemistry
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.541377/full

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https://www.frontiersin.org/article/10.3389/fneur.2020.541377/full

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