SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism

SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism

Men are disproportionately affected by the coronavirus disease-2019 (COVID-19), and face higher odds of severe illness and death compared to women. The vascular effects of androgen signaling and inflammatory cytokines in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-mediated endotheli...

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Bibliographic Details
Main Authors: Nitin Kumar, Yu Zuo, Srilakshmi Yalavarthi, Kristina L. Hunker, Jason S. Knight, Yogendra Kanthi, Andrea T. Obi, Santhi K. Ganesh
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Viruses
Subjects:
endothelial injury
androgen
COVID-19
spironolactone
angiotensin receptor blocker
E-selectin
Online Access:https://www.mdpi.com/1999-4915/13/11/2209

Internet

https://www.mdpi.com/1999-4915/13/11/2209

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