STING signalling compensates for low tumour mutation burden to drive anti-tumour immunityResearch in context

STING signalling compensates for low tumour mutation burden to drive anti-tumour immunityResearch in context

Summary: Background: While mutation-derived neoantigens are well recognized in generating anti-tumour T cell response, increasing evidences highlight the complex association between tumour mutation burden (TMB) and tumour infiltrating lymphocytes (TILs). The exploration of non-TMB determinants of a...

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Bibliographic Details
Main Authors: Jiayi Tan, Colt A. Egelston, Weihua Guo, Jeremy M. Stark, Peter P. Lee
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:EBioMedicine
Subjects:
Tumour mutation burden
Exhausted T cells
STING
Tumour microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424000707

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http://www.sciencedirect.com/science/article/pii/S2352396424000707

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