Reprogrammed astrocytes display higher neurogenic competence, migration ability and cell death resistance than reprogrammed fibroblasts

Reprogrammed astrocytes display higher neurogenic competence, migration ability and cell death resistance than reprogrammed fibroblasts

Abstract The direct reprogramming of somatic cells into induced neural progenitor cells (iNPCs) has been envisioned as a promising approach to overcome ethical and clinical issues of pluripotent stem cell transplantation. We previously reported that astrocyte-derived induced pluripotent stem cells (...

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Bibliographic Details
Main Authors: Xiaohuan Xia, Chunhong Li, Yi Wang, Xiaobei Deng, Yizhao Ma, Lu Ding, Jialin Zheng
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Translational Neurodegeneration
Subjects:
Reprogramming
Astrocyte
Fibroblast
Induced neural progenitor cells
TGFβ signaling
Neurogenesis
Online Access:https://doi.org/10.1186/s40035-020-0184-6

Internet

https://doi.org/10.1186/s40035-020-0184-6

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