Decoy Receptor 3 Suppresses T-Cell Priming and Promotes Apoptosis of Effector T-Cells in Acute Cell-Mediated Rejection: The Role of Reverse Signaling

Decoy Receptor 3 Suppresses T-Cell Priming and Promotes Apoptosis of Effector T-Cells in Acute Cell-Mediated Rejection: The Role of Reverse Signaling

BackgroundDecoy receptor 3 (DcR3) belongs to the tumor necrosis factor (TNF) receptor superfamily and neutralizes TNF ligands, including FasL and TRAIL, to prevent T activation during T-cell priming. However, the cellular mechanisms underlying acute cell-mediated rejection (ACMR) remain unknown.Meth...

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Bibliographic Details
Main Authors: Shuo-Chun Weng, Mei-Chin Wen, Shie-Liang Hsieh, Nien-Jung Chen, Der-Cherng Tarng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
adaptor protein
decoy receptor
minor antigenic determinant
knockout
phenotype
transgenic mice
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.879648/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.879648/full

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