Decoy Receptor 3 Suppresses T-Cell Priming and Promotes Apoptosis of Effector T-Cells in Acute Cell-Mediated Rejection: The Role of Reverse Signaling

Decoy Receptor 3 Suppresses T-Cell Priming and Promotes Apoptosis of Effector T-Cells in Acute Cell-Mediated Rejection: The Role of Reverse Signaling

BackgroundDecoy receptor 3 (DcR3) belongs to the tumor necrosis factor (TNF) receptor superfamily and neutralizes TNF ligands, including FasL and TRAIL, to prevent T activation during T-cell priming. However, the cellular mechanisms underlying acute cell-mediated rejection (ACMR) remain unknown.Meth...

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Bibliographic Details
Main Authors:	Shuo-Chun Weng, Mei-Chin Wen, Shie-Liang Hsieh, Nien-Jung Chen, Der-Cherng Tarng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Immunology
Subjects:	adaptor protein decoy receptor minor antigenic determinant knockout phenotype transgenic mice
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.879648/full

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