A Maternal High-Fat Diet Induces DNA Methylation Changes That Contribute to Glucose Intolerance in Offspring

A Maternal High-Fat Diet Induces DNA Methylation Changes That Contribute to Glucose Intolerance in Offspring

Scope: Overnutrition in utero is a critical contributor to the susceptibility of diabetes by programming, although the exact mechanism is not clear. In this paper, we aimed to study the long-term effect of a maternal high-fat (HF) diet on offspring through epigenetic modifications.Procedures: Five-w...

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Bibliographic Details
Main Authors: Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Endocrinology
Subjects:
DNA methylation
insulin receptor substrate
MAPK
maternal high fat diet
epigenetics
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00871/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00871/full

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