Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs

Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs

Due to its antiangiogenic and anti-immunomodulatory activity, thalidomide continues to be of clinical interest despite its teratogenic actions, and efforts to synthesize safer, clinically active thalidomide analogs are continually underway. In this study, a cohort of 27 chemically diverse thalidomid...

Full description

Bibliographic Details
Main Authors: Megan L. Peach, Shaunna L. Beedie, Cindy H. Chau, Matthew K. Collins, Suzana Markolovic, Weiming Luo, David Tweedie, Christian Steinebach, Nigel H. Greig, Michael Gütschow, Neil Vargesson, Marc C. Nicklaus, William D. Figg
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
angiogenesis
cereblon
docking
structure–activity relationships
thalidomide
Online Access:https://www.mdpi.com/1420-3049/25/23/5683

Internet

https://www.mdpi.com/1420-3049/25/23/5683

Similar Items