Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein.

Protein modifications regulate both DNA repair levels and pathway choice. How each modification achieves regulatory effects and how different modifications collaborate with each other are important questions to be answered. Here, we show that sumoylation regulates double-strand break repair partly b...

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Bibliographic Details
Main Authors: Prabha Sarangi, Roland Steinacher, Veronika Altmannova, Qiong Fu, Tanya T Paull, Lumir Krejci, Matthew C Whitby, Xiaolan Zhao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4287433?pdf=render