AAV-Mediated Combination Gene Therapy for Neuropathic Pain: GAD65, GDNF, and IL-10

AAV-Mediated Combination Gene Therapy for Neuropathic Pain: GAD65, GDNF, and IL-10

Neuropathic pain is a chronic pain state characterized by nerve damage, inflammation, and nociceptive neuron hyperactivity. As the underlying pathophysiology is complex, a more effective therapy for neuropathic pain would be one that targets multiple elements. Here, we generated recombinant adeno-as...

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Bibliographic Details
Main Authors: Daewook Kim, Kyung-Ran Kim, Yejin Kwon, Minjung Kim, Min-Ju Kim, Yeomoon Sim, Hyelin Ji, Jang-Joon Park, Jong-Ho Cho, Heonsik Choi, Sujeong Kim
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
Adeno-associated virus
Neuropathic pain
Gene therapy
glutamate decarboxylase 65
glial cell-derived neurotrophic factor
interleukin-10
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012030142X

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http://www.sciencedirect.com/science/article/pii/S232905012030142X

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