NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands

Saliva plays an essential role in the maintenance of oral health. The oral cavity environment changes during aging mainly due to alterations in the secretion and composition of saliva. In particular, unstimulated basal salivary flow decreases with age. The functional decline of the salivary glands i...

Full description

Bibliographic Details
Main Authors: Sisca Meida Wati, Daisuke Matsumaru, Hozumi Motohashi
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308089