AI-Assisted chemical probe discovery for the understudied Calcium-Calmodulin Dependent Kinase, PNCK.

PNCK, or CAMK1b, is an understudied kinase of the calcium-calmodulin dependent kinase family which recently has been identified as a marker of cancer progression and survival in several large-scale multi-omics studies. The biology of PNCK and its relation to oncogenesis has also begun to be elucidat...

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Bibliographic Details
Main Authors: Derek J Essegian, Valery Chavez, Rabia Khurshid, Jaime R Merchan, Stephan C Schürer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-05-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1010263