A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole.

A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole.

Candida albicans, the most prevalent human fungal pathogen, is generally diploid. However, 50% of isolates that are resistant to fluconazole (FLC), the most widely used antifungal, are aneuploid and some aneuploidies can confer FLC resistance. To ask if FLC exposure causes or only selects for aneupl...

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Bibliographic Details
Main Authors: Benjamin D Harrison, Jordan Hashemi, Maayan Bibi, Rebecca Pulver, Danny Bavli, Yaakov Nahmias, Melanie Wellington, Guillermo Sapiro, Judith Berman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-03-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24642609/pdf/?tool=EBI

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