A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole.

A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole.

Candida albicans, the most prevalent human fungal pathogen, is generally diploid. However, 50% of isolates that are resistant to fluconazole (FLC), the most widely used antifungal, are aneuploid and some aneuploidies can confer FLC resistance. To ask if FLC exposure causes or only selects for aneupl...

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Dettagli Bibliografici
Autori principali:	Benjamin D Harrison, Jordan Hashemi, Maayan Bibi, Rebecca Pulver, Danny Bavli, Yaakov Nahmias, Melanie Wellington, Guillermo Sapiro, Judith Berman
Natura:	Articolo
Lingua:	English
Pubblicazione:	Public Library of Science (PLoS) 2014-03-01
Serie:	PLoS Biology
Accesso online:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24642609/pdf/?tool=EBI

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