Prevention of Anti-HMGCR Immune-Mediated Necrotising Myopathy by C5 Complement Inhibition in a Humanised Mouse Model

Prevention of Anti-HMGCR Immune-Mediated Necrotising Myopathy by C5 Complement Inhibition in a Humanised Mouse Model

<b>Introduction</b>: immune-mediated necrotising myopathy (IMNM) is associated with pathogenic anti-signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibodies, at least partly through activation of the classical pathway of the complement. We evaluate...

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Bibliographic Details
Main Authors: Sarah Julien, Douangsone Vadysirisack, Camil Sayegh, Sharan Ragunathan, Yalan Tang, Emma Briand, Marion Carrette, Laetitia Jean, Rachid Zoubairi, Henri Gondé, Olivier Benveniste, Yves Allenbach, Laurent Drouot, Olivier Boyer
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
autoantibody
complement
HMGCR
immune-mediated necrotising myopathy
myositis
Online Access:https://www.mdpi.com/2227-9059/10/8/2036

Internet

https://www.mdpi.com/2227-9059/10/8/2036

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