The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo

The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo

Inhibition of the interaction between the scaffolding protein PSD-95 and the NMDA receptor has been shown to obstruct ischemic stroke-triggered excitotoxic reactions, leading to neuronal death. The peptides NR2B9c and N-dimer are inhibitors of this interaction. Delivery of the peptides to the brain...

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Bibliographic Details
Main Authors: Emma Lisa Al Humaidan, Sidse Lund Pedersen, Annette Burkhart, Charlotte Laurfelt Munch Rasmussen, Torben Moos, Peter Fuchs, Eduardo Filipe Alves Fernandes, Burak Ozgür, Kristian Strømgaard, Anders Bach, Birger Brodin, Mie Kristensen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Drug Delivery
Subjects:
blood-brain barrer
cell-penetrating peptide
brain drug delivery
ischemic stroke
tat
Online Access:https://www.frontiersin.org/articles/10.3389/fddev.2022.854703/full

Internet

https://www.frontiersin.org/articles/10.3389/fddev.2022.854703/full

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