15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism

15(S)-lipoxygenase-1 (15-LO-1) was present in the whole-cell homogenate of an acute human monocytic leukemia cell line (THP-1). Additionally, 15-LO-1 was detected on neutral lipid droplets isolated from THP-1 foam cells. To investigate if 15-LO-1 is active on lipid droplets, we used the mouse leukem...

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Bibliographic Details
Main Authors: Ginny L. Weibel, Michelle R. Joshi, Cong Wei, Sandra R. Bates, Ian A. Blair, George H. Rothblat
Format: Article
Language:English
Published: Elsevier 2009-12-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752030660X