Metabolic regulation of forkhead box P3 alternative splicing isoforms and their impact on health and disease

Metabolic regulation of forkhead box P3 alternative splicing isoforms and their impact on health and disease

Forkhead Box P3 (FOXP3) is crucial for the development and suppressive function of human regulatory T cells (Tregs). There are two predominant FOXP3 splicing isoforms in healthy humans, the full-length isoform and the isoform lacking exon 2, with different functions and regulation mechanisms. FOXP3...

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Bibliographic Details
Main Authors: Zhidan Luo, Yihua Zhang, Qais Waleed Saleh, Jie Zhang, Zhiming Zhu, Martin Tepel
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
forkhead box P3
splicing isoforms
metabolic regulation
regulatory T cells
suppressive function
glycolysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1278560/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1278560/full

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