A Novel Monoclonal Antibody Targeting Cancer-Specific Plectin Has Potent Antitumor Activity in Ovarian Cancer

A Novel Monoclonal Antibody Targeting Cancer-Specific Plectin Has Potent Antitumor Activity in Ovarian Cancer

Cancer-specific plectin (CSP) is a pro-tumorigenic protein selectively expressed on the cell surface of major cancers, including ovarian cancer (OC). Despite its assessable localization, abundance, and functional significance, the therapeutic efficacy of targeting CSP remains unexplored. Here, we ge...

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Bibliographic Details
Main Authors: Samantha M. Perez, Julien Dimastromatteo, Charles N. Landen, Kimberly A. Kelly
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
plectin
monoclonal antibody
ovarian cancer
JAK2/STAT3 signaling
cisplatin
combination therapy
Online Access:https://www.mdpi.com/2073-4409/10/9/2218

Internet

https://www.mdpi.com/2073-4409/10/9/2218

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