Identification of a critical sulfation in chondroitin that inhibits axonal regeneration
The failure of mammalian CNS neurons to regenerate their axons derives from a combination of intrinsic deficits and extrinsic factors. Following injury, chondroitin sulfate proteoglycans (CSPGs) within the glial scar inhibit axonal regeneration, an action mediated by the sulfated glycosaminoglycan (...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-05-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/37139 |