Identification of a critical sulfation in chondroitin that inhibits axonal regeneration

Identification of a critical sulfation in chondroitin that inhibits axonal regeneration

The failure of mammalian CNS neurons to regenerate their axons derives from a combination of intrinsic deficits and extrinsic factors. Following injury, chondroitin sulfate proteoglycans (CSPGs) within the glial scar inhibit axonal regeneration, an action mediated by the sulfated glycosaminoglycan (...

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Bibliographic Details
Main Authors: Craig S Pearson, Caitlin P Mencio, Amanda C Barber, Keith R Martin, Herbert M Geller
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
proteoglycan
arylsulfatase B
chondroitinase ABC
optic nerve crush
cell culture
Online Access:https://elifesciences.org/articles/37139

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