Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism

Pancreatic islet failure, involving loss of glucose-stimulated insulin secretion (GSIS) from islet β cells, heralds the onset of type 2 diabetes (T2D). To search for mediators of GSIS, we performed metabolomics profiling of the insulinoma cell line 832/13 and uncovered significant glucose-induced ch...

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Bibliographic Details
Main Authors: Jessica R. Gooding, Mette V. Jensen, Xiaoqing Dai, Brett R. Wenner, Danhong Lu, Ramamani Arumugam, Mourad Ferdaoussi, Patrick E. MacDonald, Christopher B. Newgard
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715009857

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http://www.sciencedirect.com/science/article/pii/S2211124715009857

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