Summary of the DREAM8 Parameter Estimation Challenge: Toward Parameter Identification for Whole-Cell Models.

Summary of the DREAM8 Parameter Estimation Challenge: Toward Parameter Identification for Whole-Cell Models.

Whole-cell models that explicitly represent all cellular components at the molecular level have the potential to predict phenotype from genotype. However, even for simple bacteria, whole-cell models will contain thousands of parameters, many of which are poorly characterized or unknown. New algorith...

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Bibliographic Details
Main Authors: Jonathan R Karr, Alex H Williams, Jeremy D Zucker, Andreas Raue, Bernhard Steiert, Jens Timmer, Clemens Kreutz, DREAM8 Parameter Estimation Challenge Consortium, Simon Wilkinson, Brandon A Allgood, Brian M Bot, Bruce R Hoff, Michael R Kellen, Markus W Covert, Gustavo A Stolovitzky, Pablo Meyer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-05-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4447414?pdf=render

Internet

http://europepmc.org/articles/PMC4447414?pdf=render

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