Proteogenomic analysis of melanoma brain metastases from distinct anatomical sites identifies pathways of metastatic progression

Proteogenomic analysis of melanoma brain metastases from distinct anatomical sites identifies pathways of metastatic progression

Abstract Melanoma brain metastases (MBM) portend a grim prognosis and can occur in up to 40% of melanoma patients. Genomic characterization of brain metastases has been previously carried out to identify potential mutational drivers. However, to date a comprehensive multi-omics approach has yet to b...

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Bibliographic Details
Main Authors: Erin M. Taylor, Stephanie D. Byrum, Jacob L. Edmondson, Christopher P. Wardell, Brittany G. Griffin, Sara C. Shalin, Murat Gokden, Issam Makhoul, Alan J. Tackett, Analiz Rodriguez
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Acta Neuropathologica Communications
Subjects:
Melanoma
Brain metastases
Proteomics
Proteogenomics
Multi-omics
PIK3CG
Online Access:http://link.springer.com/article/10.1186/s40478-020-01029-x

Internet

http://link.springer.com/article/10.1186/s40478-020-01029-x

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