Overelaborated synaptic architecture and reduced synaptomatrix glycosylation in a Drosophila classic galactosemia disease model

Overelaborated synaptic architecture and reduced synaptomatrix glycosylation in a Drosophila classic galactosemia disease model

Classic galactosemia (CG) is an autosomal recessive disorder resulting from loss of galactose-1-phosphate uridyltransferase (GALT), which catalyzes conversion of galactose-1-phosphate and uridine diphosphate (UDP)-glucose to glucose-1-phosphate and UDP-galactose, immediately upstream of UDP–N-acetyl...

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Bibliographic Details
Main Authors: Patricia Jumbo-Lucioni, William Parkinson, Kendal Broadie
Format: Article
Language:English
Published: The Company of Biologists 2014-12-01
Series:Disease Models & Mechanisms
Subjects:
Congenital disorder of glycosylation (CDG)
sugarless
Galactokinase
Synaptogenesis
Trans-synaptic signaling
WNT
HSPG
Neuromuscular junction
Online Access:http://dmm.biologists.org/content/7/12/1365

Internet

http://dmm.biologists.org/content/7/12/1365

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