Micro- and Nano-vesicles from First Trimester Human Placentae Carry Flt-1 and Levels Are Increased in Severe Preeclampsia

Background/objectivesPreeclampsia is a life-threatening hypertensive disease affecting 3–5% of pregnancies. While the pathogenesis of preeclampsia remains unclear, it is known that placenta-derived factors trigger the disease by activating maternal endothelial cells prior to the onset of clinical sy...

Full description

Bibliographic Details
Main Authors: Mancy Tong, Qi Chen, Joanna L. James, Peter R. Stone, Lawrence W. Chamley
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Endocrinology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00174/full