Analysis of monoclonal immunoglobulins from bone marrow plasma cells using immunopurification and LC-MS

Introduction: Clonal plasma cells secrete immunoglobulins, each with the exact same amino acid sequence, that are referred to as monoclonal immunoglobulins. The monoclonal heavy chain and light chain secreted from clonal plasma cells have the same molecular mass prior to the addition of post-transla...

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Bibliographic Details
Main Authors: David R. Barnidge, Angela Dispenzieri, Dragan Jevremovic, David L. Murray
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Journal of Mass Spectrometry and Advances in the Clinical Lab
Online Access:http://www.sciencedirect.com/science/article/pii/S2667145X23000226