Transforming Growth Factor Beta and Alveolar Rhabdomyosarcoma: A Challenge of Tumor Differentiation and Chemotherapy Response

Transforming Growth Factor Beta and Alveolar Rhabdomyosarcoma: A Challenge of Tumor Differentiation and Chemotherapy Response

Alveolar rhabdomyosarcoma (ARMS), an invasive subtype of rhabdomyosarcoma (RMS), is associated with chromosomal translocation events resulting in one of two oncogenic fusion genes, <i>PAX3-FOXO1</i> or <i>PAX7-FOXO1</i>. ARMS patients exhibit an overexpression of the pleiotro...

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Bibliographic Details
Main Authors: Bhavya Bhushan, Rosa Iranpour, Amirmohammad Eshtiaghi, Simone C. da Silva Rosa, Benjamin W. Lindsey, Joseph W. Gordon, Saeid Ghavami
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
rhabdomyosarcoma
combination therapy
all-trans retinoic acid
TGF-beta1
Online Access:https://www.mdpi.com/1422-0067/25/5/2791

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https://www.mdpi.com/1422-0067/25/5/2791

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