Tensin-2 interactomics reveals interaction with GAPDH and a phosphorylation-mediated regulatory role in glycolysis

Abstract Integrin adaptor proteins, like tensin-2, are crucial for cell adhesion and signaling. However, the function of tensin-2 beyond localizing to focal adhesions remain poorly understood. We utilized proximity-dependent biotinylation and Strep-tag affinity proteomics to identify interaction par...

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Autori principali: Paula Turkki, Iftekhar Chowdhury, Tiina Öhman, Latifeh Azizi, Markku Varjosalo, Vesa P. Hytönen
Natura: Articolo
Lingua:English
Pubblicazione: Nature Portfolio 2024-08-01
Serie:Scientific Reports
Accesso online:https://doi.org/10.1038/s41598-024-65787-7