2.7 THE GUT-DERIVED METABOLITE TRIMETHYLAMINE N-OXIDE INDUCES LARGE ELASTIC ARTERY STIFFENING AND ENDOTHELIAL DYSFUNCTION IN YOUNG MICE
The gut microbiome, an emerging mediator of host physiological function, is adversely altered by aging and many diseases, termed “gut dysbiosis.” One consequence of gut dysbiosis is elevated circulating levels of the gut-derived metabolite trimethylamine N-oxide (TMAO), which has been directly linke...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-12-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125930212/view |