Th22 Cells Promote Osteoclast Differentiation via Production of IL-22 in Rheumatoid Arthritis

Th22 Cells Promote Osteoclast Differentiation via Production of IL-22 in Rheumatoid Arthritis

T helper (Th) cells can differentiate into functionally distinct subsets and play a pivotal role in inflammatory and autoimmune diseases such as rheumatoid arthritis (RA). Th22 cells have been identified as a new subset secreting interleukin (IL)-22. Although elevated levels of IL-22 in the synovial...

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Bibliographic Details
Main Authors: Yusuke Miyazaki, Shingo Nakayamada, Satoshi Kubo, Kazuhisa Nakano, Shigeru Iwata, Ippei Miyagawa, Xiaoxue Ma, Gulzhan Trimova, Kei Sakata, Yoshiya Tanaka
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
Th22 cell
osteoclastogenesis
IL-22
TNFα
IL-6
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02901/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02901/full

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