Brain-Derived Neurotrophic Factor Is an Important Therapeutic Factor in Mesenchymal Stem Cell Secretions for Treatment of Traumatic Peripheral Pelvic Injuries

Brain-Derived Neurotrophic Factor Is an Important Therapeutic Factor in Mesenchymal Stem Cell Secretions for Treatment of Traumatic Peripheral Pelvic Injuries

Traumatic neuromuscular injury to the pudendal nerve and urethra during childbirth does not regenerate well and contributes to stress urinary incontinence in women. Mesenchymal stem cells (MSCs) can improve neuroregeneration via their secretions, or secretome, which includes brain-derived neurotroph...

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Bibliographic Details
Main Authors: Xiaoyi Yuan, Brian M. Balog, Dan Li Lin, Brett Hanzlicek, Mei Kuang, Hao Yan, Steve J. A. Majerus, Margot S. Damaser
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
siRNA knockdown
leak point pressure
neuromuscular junctions
reinnervation
urethra
external urethral sphincter
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.866094/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.866094/full

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