What if Cocrystallization Fails for Neutral Molecules? Screening Offered Eutectics as Alternate Pharmaceutical Materials: Leflunomide-a Case Study

What if Cocrystallization Fails for Neutral Molecules? Screening Offered Eutectics as Alternate Pharmaceutical Materials: Leflunomide-a Case Study

Background: The manuscript is aimed to optimize the biopharmaceutical parameters of a poorly soluble, neutral anti-rheumatic drug ‘leflunomide’ by preparing its non-covalent derivatives (NCDs). For this various monocarboxylic acids- (adipic acid, picolinic acid) and dicarboxylic acids (maleic ac...

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Bibliographic Details
Main Authors: Madhu Bala, Manoj Kumar Gautam, Renu Chadha
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2019-09-01
Series:Pharmaceutical Sciences
Subjects:
Eutectics
Phase diagrams
Heat of mixing
Pharmaceutical properties
Physical stability
Online Access:https://ps.tbzmed.ac.ir/PDF/PHARM_24134_20180727153944

Internet

https://ps.tbzmed.ac.ir/PDF/PHARM_24134_20180727153944

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