A critical evaluation of protein kinase regulation by activation loop autophosphorylation

A critical evaluation of protein kinase regulation by activation loop autophosphorylation

Phosphorylation of proteins is a ubiquitous mechanism of regulating their function, localization, or activity. Protein kinases, enzymes that use ATP to phosphorylate protein substrates are, therefore, powerful signal transducers in eukaryotic cells. The mechanism of phosphoryl-transfer is universall...

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Bibliographic Details
Main Authors: Ronja Reinhardt, Thomas A Leonard
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-07-01
Series:eLife
Subjects:
kinase
allostery
inhibition
activation
phosphorylation
dimerization
Online Access:https://elifesciences.org/articles/88210

Internet

https://elifesciences.org/articles/88210

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