Taking out the garbage: cathepsin D and calcineurin in neurodegeneration

Taking out the garbage: cathepsin D and calcineurin in neurodegeneration

Cellular homeostasis requires a tightly controlled balance between protein synthesis, folding and degradation. Especially long-lived, post-mitotic cells such as neurons depend on an efficient proteostasis system to maintain cellular health over decades. Thus, a functional decline of processes contri...

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Bibliographic Details
Main Authors: Andreas Aufschnaiter, Verena Kohler, Sabrina Büttner
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Neural Regeneration Research
Subjects:
neurodegeneration; Parkinson′s disease; α-synuclein; cathepsin D
calcineurin; retromer; yeast; lysosome; endosomal sorting
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=11;spage=1776;epage=1779;aulast=Aufschnaiter

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=11;spage=1776;epage=1779;aulast=Aufschnaiter

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