Astragaloside IV Blunts Epithelial–Mesenchymal Transition and G2/M Arrest to Alleviate Renal Fibrosis via Regulating ALDH2-Mediated Autophagy

Astragaloside IV Blunts Epithelial–Mesenchymal Transition and G2/M Arrest to Alleviate Renal Fibrosis via Regulating ALDH2-Mediated Autophagy

Previous studies show that astragaloside IV (ASIV) has anti-renal fibrosis effects. However, its mechanism remains elusive. In this study, we investigated the anti-fibrosis mechanisms of ASIV on chronic kidney disease (CKD) in vivo and in vitro. A CKD model was induced in rats with adenine (200 mg/k...

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Bibliographic Details
Main Authors: Dong Li, Yuzhe Liu, Quancao Zhan, Yan Zeng, Ze Peng, Qifeng He, Qi Tan, Wenfu Cao, Shang Wang, Jianwei Wang
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
renal fibrosis
astragaloside IV
ALDH2
autophagy
AKT/mTOR
Online Access:https://www.mdpi.com/2073-4409/12/13/1777

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https://www.mdpi.com/2073-4409/12/13/1777

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