Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype
The bivalent hypothesis posits that genes encoding developmental regulators required for early lineage decisions are poised in stem/progenitor cells by the balance between a repressor histone modification (H3K27me3), mediated by the Polycomb Repressor Complex 2 (PRC2), and an activator modification...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2014-09-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/04235 |