Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype

Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype

The bivalent hypothesis posits that genes encoding developmental regulators required for early lineage decisions are poised in stem/progenitor cells by the balance between a repressor histone modification (H3K27me3), mediated by the Polycomb Repressor Complex 2 (PRC2), and an activator modification...

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Bibliographic Details
Main Authors: James C McGann, Jon A Oyer, Saurabh Garg, Huilan Yao, Jun Liu, Xin Feng, Lujian Liao, John R Yates III, Gail Mandel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-09-01
Series:eLife
Subjects:
ES cell
REST
Polycomb
poised
histone deacetylase
neuronal
Online Access:https://elifesciences.org/articles/04235

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