DNMT1 constrains IFNβ-mediated anti-tumor immunity and PD-L1 expression to reduce the efficacy of radiotherapy and immunotherapy

DNMT1 constrains IFNβ-mediated anti-tumor immunity and PD-L1 expression to reduce the efficacy of radiotherapy and immunotherapy

Radiotherapy can boost the therapeutic response to immune checkpoint inhibitors (ICIs) by recruiting T lymphocytes and upregulating PD-L1 expression within the tumor microenvironment (TME). However, in some cases, tumor PD-L1 expression cannot be induced, even in the presence of abundant T lymphocyt...

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Bibliographic Details
Main Authors: Kevin Chih-Yang Huang, Shu-Fen Chiang, Tao-Wei Ke, Tsung-Wei Chen, Ching-Han Hu, Pei-Chen Yang, Hsin-Yu Chang, Ji-An Liang, William Tzu-Liang Chen, K. S. Clifford Chao
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
locally advanced rectal cancer
anti-pd-l1 immunotherapy
dnmt1
radiotherapy
type i ifn
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1989790

Internet

http://dx.doi.org/10.1080/2162402X.2021.1989790

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