Two‐ and three‐dimensional in vitro nucleus pulposus cultures: An in silico analysis of local nutrient microenvironments

Abstract Background It is well established that the unique biochemical microenvironment of the intervertebral disc plays a predominant role in cell viability and biosynthesis. However, unless the effect of microenvironmental conditions is primary to a study objective, in vitro culture parameters tha...

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Bibliographic Details
Main Authors: Emily E. McDonnell, Conor T. Buckley
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:JOR Spine
Subjects:
Online Access:https://doi.org/10.1002/jsp2.1222