Increased sinusoidal pressure impairs liver endothelial mechanosensing, uncovering novel biomarkers of portal hypertension

Increased sinusoidal pressure impairs liver endothelial mechanosensing, uncovering novel biomarkers of portal hypertension

Background & Aims: Portal hypertension (PH) is a frequent and severe clinical syndrome associated with chronic liver disease. Considering the mechanobiological effects of hydrostatic pressure and shear stress on endothelial cells, we hypothesised that PH might influence the phenotype of live...

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Bibliographic Details
Main Authors: Martí Ortega-Ribera, Albert Gibert-Ramos, Laia Abad-Jordà, Marta Magaz, Luis Téllez, Lorena Paule, Elisa Castillo, Raül Pastó, Bruno de Souza Basso, Pol Olivas, Lara Orts, Juan José Lozano, Rosa Villa, Jaime Bosch, Agustín Albillos, Joan Carles García-Pagán, Jordi Gracia-Sancho
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:JHEP Reports
Subjects:
Liver sinusoidal endothelial cells
LSEC
Hepatic haemodynamic
Liver cirrhosis
HVPG
Endothelial dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923000538

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http://www.sciencedirect.com/science/article/pii/S2589555923000538

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