Generation of an NFκB-Driven Alpharetroviral “All-in-One” Vector Construct as a Potent Tool for CAR NK Cell Therapy

Generation of an NFκB-Driven Alpharetroviral “All-in-One” Vector Construct as a Potent Tool for CAR NK Cell Therapy

Immune cell therapeutics are increasingly applied in oncology. Especially chimeric antigen receptor (CAR) T cells are successfully used to treat several B cell malignancies. Efforts to engineer CAR T cells for improved activity against solid tumors include co-delivery of pro-inflammatory cytokines i...

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Bibliographic Details
Main Authors: Loreen Sophie Rudek, Katharina Zimmermann, Melanie Galla, Johann Meyer, Johannes Kuehle, Andriana Stamopoulou, Daniel Brand, I. Erol Sandalcioglu, Belal Neyazi, Thomas Moritz, Claudia Rossig, Bianca Altvater, Christine S. Falk, Hinrich Abken, Michael Alexander Morgan, Axel Schambach
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
immunotherapy
NK cells
chimeric antigen receptor (CAR)
tumor microenvironment
immunomodulatory cytokines
alpharetroviral vectors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.751138/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.751138/full

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