Potent in vivo efficacy of oral gallium maltolate in treatment-resistant glioblastoma

Potent in vivo efficacy of oral gallium maltolate in treatment-resistant glioblastoma

BackgroundTreatment-resistant glioblastoma (trGBM) is an aggressive brain tumor with a dismal prognosis, underscoring the need for better treatment options. Emerging data indicate that trGBM iron metabolism is an attractive therapeutic target. The novel iron mimetic, gallium maltolate (GaM), inhibit...

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Bibliographic Details
Main Authors: Mona M. Al-Gizawiy, Robert T. Wujek, Hisham S. Alhajala, Jonathan M. Cobb, Melissa A. Prah, Ninh B. Doan, Jennifer M. Connelly, Christopher R. Chitambar, Kathleen M. Schmainda
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Oncology
Subjects:
glioblastoma
iron
gallium
treatment
xenograft
MRI
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1278157/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1278157/full

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